Due to New York State Department of Health regulations, we cannot ship to New York residents. All orders from the state of New York will be cancelled.

Nickel is a common metal found in everyday objects, food, and the environment. For some individuals, exposure can trigger allergic reactions, ranging from skin irritation to systemic symptoms. The Nickel Sensitivity Genetic Test analyses specific genetic markers to determine your predisposition to nickel-related allergies. By understanding your genetic susceptibility, you can take proactive steps to minimize exposure and manage symptoms effectively.

This test examines genetic variations in the FLG (Filaggrin) and TNF-α (Tumor Necrosis Factor Alpha) genes, both of which play a role in how your body reacts to nickel exposure.

🔹 Your Genetic Predisposition: The test identifies whether you have genetic variants that increase your sensitivity to nickel.
🔹 Potential Symptoms: Learn whether you’re at higher risk for conditions such as allergic contact dermatitis or Systemic Nickel Allergy Syndrome (SNAS) – a reaction that can cause digestive issues, headaches, and chronic fatigue.
🔹 Personalized Risk Management: Get actionable insights on how to reduce exposure, adjust your diet, and improve skin health to prevent allergic reactions.

For an example of the report, please click here:

Genetic testing examines key variants in two genes:

• FLG Gene (Filaggrin):
  This gene is crucial for maintaining the skin barrier. Mutations in FLG can:
  ✔ Weaken the skin’s ability to block allergens like nickel.
  ✔ Increase the risk of allergic contact dermatitis (itching, redness, and inflammation).
  ✔ Lead to chronic skin dryness and irritation.

• TNF-α Gene (Tumour Necrosis Factor Alpha):
  This gene regulates inflammatory responses. Certain variants can:
  ✔ Trigger excessive immune reactions to nickel exposure.
  ✔ Increase the likelihood of chronic inflammation and allergic dermatitis.
  ✔ Contribute to systemic symptoms such as digestive discomfort, fatigue, and headaches.

By identifying whether you carry high-risk genetic variants, this test helps you understand why you may react to nickel and how to manage your sensitivity more effectively.

A Nickel Sensitivity DNA test does not require you to provide a blood sample. Our test is performed using buccal swabs that we provide in our home sample collection kit. Collecting samples is quick and easy if you follow the instructions provided carefully.

Sample collection instructions can be found on our “How to Collect DNA Samples” page.

Please read our terms and conditions for clinical and health-related testing carefully and make sure you understand them before placing an order.

Please contact us with any questions or to place an order

We also offer tests to determine your predisposition to disease, coeliac disease, lactose intolerance and your lipid metabolism. For more information, please click here.

If you’re interested in how your genes impact more than just caffeine metabolism, you might want to explore our Sport DNA Test, which can reveal your ideal sport and even provide a personalized training plan based on your genetic profile.

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