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The MacroMatch DNA Test is an advanced genetic analysis designed to provide personalized insights into how your body processes macronutrients (carbohydrates, proteins, and fats) and caffeine. By analysing your DNA, this test helps you tailor your diet, fitness, and lifestyle to your genetic profile, allowing for optimized nutrition, improved performance, and better well-being.

With the MacroMatch DNA Test, you’ll discover:

• Your Ideal Macronutrient Balance – Find out how your body metabolizes carbohydrates, fats, and proteins to optimize energy, weight management, and muscle growth.
• Your Caffeine Sensitivity – Learn whether you are a fast or slow metabolizer of caffeine and how it affects your focus, sleep, and cardiovascular health.
• Genetic Factors Influencing Your Metabolism – Understand how specific gene variants impact your digestion, energy levels, and nutrient absorption.
• Personalized Nutrition and Fitness Recommendations – Get tailored diet and exercise strategies based on your unique genetic profile to support your health and fitness goals.

For an example of the report, please click here:

For an example of the report, please click here:

The MacroMatch DNA Test is grounded in the latest advancements in nutrigenetics, analysing key genetic markers that impact how your body processes carbohydrates, fats, proteins, and caffeine. By identifying these genetic variants, the test offers personalized insights into metabolism, energy utilization, and overall health.

Carbohydrate Metabolism: Insulin Sensitivity & Glucose Regulation

Your body’s ability to process carbohydrates and regulate blood sugar levels depends on several key genes:

🧬 PPARG (Peroxisome Proliferator-Activated Receptor Gamma)

• Regulates lipid and carbohydrate metabolism and plays a crucial role in insulin sensitivity.
• Certain variants are linked to an increased risk of insulin resistance and obesity.

🧬 KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11)

• Encodes a protein that helps regulate insulin secretion from pancreatic beta cells.
• Variants may affect blood sugar control, contributing to an increased risk of type 2 diabetes.

🧬 TCF7L2 (Transcription Factor 7 Like 2)

• Plays a pivotal role in insulin regulation and glucose sensitivity.
• Some genetic variants in TCF7L2 are among the strongest known risk factors for type 2 diabetes, impacting how the body processes carbohydrates.

Lipid Metabolism: Fat Storage & Cardiovascular Health

Certain genetic markers influence how efficiently your body metabolizes fats and regulates cholesterol levels:

🧬 APOA1 (Apolipoprotein A1)

• A key component of HDL (“good” cholesterol), which helps remove excess cholesterol from the bloodstream.
• Variants may affect HDL levels and cardiovascular risk.

🧬 APOC3 (Apolipoprotein C3)

• Regulates triglyceride metabolism, influencing fat storage and the risk of metabolic syndrome.

🧬 CETP (Cholesteryl Ester Transfer Protein)

• Governs the transfer of cholesterol between lipoproteins.
• Genetic variants can impact HDL and LDL cholesterol levels, influencing heart health.

🧬 LDLR (Low-Density Lipoprotein Receptor)

• Responsible for removing LDL (“bad” cholesterol) from the bloodstream.
• Mutations can increase the risk of high cholesterol and atherosclerosis.

Protein Metabolism: Muscle Maintenance & Recovery

Protein metabolism is essential for muscle growth, repair, and overall body composition. The following genes play a critical role:

🧬 ACTN3 (Alpha-Actinin-3)

• Influences muscle fiber composition, determining whether you are predisposed to explosive strength or endurance performance.
• Certain variants are associated with muscle strength and power, affecting athletic performance.

🧬 FTO (Fat Mass and Obesity-Associated Gene)

• Regulates appetite, protein synthesis, and body composition.
• Variants can affect lean muscle mass retention, impacting metabolism and weight management.

🧬 MTHFR (Methylenetetrahydrofolate Reductase)

• Essential for homocysteine and folate metabolism, which influences amino acid synthesis and DNA repair.
• Variants may affect protein metabolism, inflammation, and muscle recovery.

Caffeine Metabolism: Sensitivity & Performance Effects

Caffeine affects energy levels, cognitive function, and cardiovascular health, and its metabolism is determined by:

🧬 CYP1A2 (Cytochrome P450 1A2)

• Encodes the liver enzyme responsible for breaking down caffeine.
• Determines whether you are a fast or slow metabolizer, influencing caffeine’s effects on sleep, anxiety, and blood pressure.

A Nickel Sensitivity DNA test does not require you to provide a blood sample. Our test is performed using buccal swabs that we provide in our home sample collection kit. Collecting samples is quick and easy if you follow the instructions provided carefully.

Sample collection instructions can be found on our “How to Collect DNA Samples” page.

Please read our terms and conditions for clinical and health-related testing carefully and make sure you understand them before placing an order.

Please contact us with any questions or to place an order

We also offer tests to determine your predisposition to disease, coeliac disease, lactose intolerance and your lipid metabolism. For more information, please click here.

If you’re interested in how your genes impact more than just caffeine metabolism, you might want to explore our Sport DNA Test, which can reveal your ideal sport and even provide a personalized training plan based on your genetic profile.

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